dc.contributor.advisor | Hossain, Dr. M. Mahboob | |
dc.contributor.author | Jannat, Taslimun | |
dc.date.accessioned | 2020-08-31T14:47:51Z | |
dc.date.available | 2020-08-31T14:47:51Z | |
dc.date.copyright | 2019 | |
dc.date.issued | 2019-09 | |
dc.identifier.other | ID 18376005 | |
dc.identifier.uri | http://hdl.handle.net/10361/14024 | |
dc.description | This thesis report is submitted in partial fulfillment of the requirement for the degree of Master of Science in Biotechnology, 2019. | en_US |
dc.description | Catalogued from PDF version of thesis. | |
dc.description | Includes bibliographical references (pages 34-39). | |
dc.description.abstract | Bacteriophages, the most abundant and diverse entities in the biosphere which are composed
of a nucleic acid molecule that is surrounded by a protein structure. These viruses can infect or
kill bacteria through lytic and lysogenic cycle, however, the bacteria have evolved their own
defense system to protect themselves from the integration of foreign mobile genetic elements
through CRISPR-Cas that utilizes short foreign DNA sequences, known as spacers. Since it is
their defense mechanism, therefore the correlation of abundance between the spacers and the
prophages are expected to be inversely proportional. The project was designed to find the
relationship between the total number of spacers and the prophages through computational
approach. The finding of this thesis conflict with expected outcome since regression line do
not demonstrate significant changes when analyzed. Moreover, almost 33% bacterial genomes
were found to carry prophages even in the presence of spacers those align with them and the
number of spacers increases with the increase of prophage length. In spite of being present in
bacterial genome along with spacers, they do not share any core genes indicate that not any
specific types of prophages have these special capacity to infect bacteria in presence of spacer
rather they are of different species. | en_US |
dc.description.statementofresponsibility | Taslimun Jannat | |
dc.format.extent | 39 pages | |
dc.language.iso | en_US | en_US |
dc.publisher | Brac University | en_US |
dc.rights | Brac University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. | |
dc.subject | Bacteria | en_US |
dc.subject | Bacteriophage | en_US |
dc.subject | Prophage | en_US |
dc.subject | Genome | en_US |
dc.subject | Spacers | en_US |
dc.title | A study to investigate the correlation of abundance between the spacers and the prophages in bacterial genome | en_US |
dc.type | Thesis | en_US |
dc.contributor.department | Department of Mathematics and Natural Sciences, Brac University | |
dc.description.degree | M. Biotechnology | |