Dr. Eva Rahman Kabir
http://hdl.handle.net/10361/6574
2024-03-28T10:04:54Z
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Impact of cadmium exposure on human health with a focus on Bangladesh
http://hdl.handle.net/10361/7089
Impact of cadmium exposure on human health with a focus on Bangladesh
Kabir, Eva Rahman; Sheikh, Zara; Khan, Tanisha Tabassum Sayka
The environment in which we claim to “live” in has become a huge reservoir of toxic metals. Human
health is under constant risk of deterioration due to increasing chronic exposure of such metals that adversely affect
the quality of life of people. The deterioration of human health due to exposure to heavy metals has become a major
issue of concern worldwide. Although adverse health effects caused by heavy metals have been known for a long
time, exposure to heavy metals continues, and is even increasing in some parts of the world, particularly in less
developed countries, even though emissions have declined in most developed countries over the last 100 years. One
such heavy metal with a high toxicity found in the earth’s crust, associated with zinc, lead and copper ores is
cadmium. Exposure to cadmium has long been recognized as a health hazard, both in industry and in general
populations with high exposure. However, cadmium is toxic at very low exposure levels and has acute and chronic
effects on health and environment which is thus the cause of great concern. The parts of body that are potentially
affected from exposures to cadmium mainly involve the kidney, liver, lung, heart and bone. If one is exposed to
cadmium or cadmium compounds, a number of factors will determine whether or not the person will be affected.
These factors include not only dose and duration of contact, how he/she comes in contact with it but parameters such
as age, sex, diet, family traits, lifestyle, and state of health also tend to contribute to determine the extent of exposure
(ATSDR, 2012). The objective of this paper is to review available information on possible toxicities of cadmium on
human health. Our aim in this study was to identify the possible impacts of cadmium on human health, with the
ultimate goal of proposing the rationale for future quantitative research of cadmium in Bangladesh
This article was published in the European Journal of Toxicological Sciences [© 2014 European Journal of Toxicological Sciences] and the definite version is available at: https://goo.gl/v3JGjq
2014-03-01T00:00:00Z
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A pragmatic approach to the analysis of a combination formulation
http://hdl.handle.net/10361/6813
A pragmatic approach to the analysis of a combination formulation
Mubtasim, Noshin; Kabir, Eva Rahman; Podder, Ashis Kumar; Bhadra, Subrata
The aim of the paper was to formulate a combined oral dosage form of rosuvastatin calcium and amlodipine besylate and to develop and validate an analytical method to be adopted for both routine quality control assay and in vitro dissolution studies of the formulation.
The proposed combination formulation has shown compatibility with the chosen excipients, verified through FT-IR study. A novel gradient RP-HPLC method was developed and validated according to the ICH guideline which was found to be suitable for the simultaneous estimation of rosuvastatin calcium and amlodipine besylate from the formulation. The retention time of 2.7 and 6.08 min allows the analysis of large amount of samples with less mobile phase which makes the method economic. The dissolution profiles of both the drugs in different dissolution medium were encouraging which makes the combination formulation of rosuvastatin calcium and amlodipine besylate superior and effective in achieving patient compliance.
This article was published in the Saudi Pharmaceutical Journal [© 2016 Elsevier B.V.] and the definite version is available at: http://www.sciencedirect.com/science/article/pii/S1319016415001152
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A review on endocrine disruptors and their possible impacts on human health
http://hdl.handle.net/10361/6802
A review on endocrine disruptors and their possible impacts on human health
Kabir, Eva Rahman; Rahman, Monica Sharfin; Rahman, Imon
Endocrine disruption is a named field of research which has been very active for over 10 years, although the effects of endocrine disruptors in wildlife have been studied mainly in vast since the 1940s. A large number of chemicals have been identified as endocrine disruptors and humans can be exposed to them either due to their occupations or through dietary and environmental exposure (water, soil and air). Endocrine disrupting chemicals are compounds that alter the normal functioning of the endocrine system of both humans and wildlife. In order to understand the vulnerability and risk factors of people due to endocrine disruptors as well as the remedies for these, methods need to be developed in order to predict effects on populations and communities from the knowledge of effects on individuals. For several years there have been a growing interest on the mechanism and effect of endocrine disruptors and their relation with environment and human health effect. This paper, based on extensive literature survey, briefly studies the progress mainly in human to provide information concerning causative substances, mechanism of action, ubiquity of effects and important issues related to endocrine disruptors. It also reviews the current knowledge of the potential impacts of endocrine disruptors on human health so that the effects can be known and remedies applied for the problem as soon as possible.
This article was published in Environmental Toxicology and Pharmacology [© 2015 Elsevier] and the definite version is available at: http://ac.els-cdn.com/S1382668915300120/1-s2.0-S1382668915300120-main.pdf?_tid=d5159a04-b538-11e6-896c-00000aacb362&acdnat=1480316818_f9b89a84cd4da21a57f6ff9c6a98c96a The article website is at: http://www.sciencedirect.com/science/article/pii/S1382668915300120
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Different approaches in the treatment of obstructive pulmonary diseases
http://hdl.handle.net/10361/6798
Different approaches in the treatment of obstructive pulmonary diseases
Kabir, Eva Rahman; Morshed, Nabila
Advances in drug formulation, inhalation device design and disease management are generating new opportunities for patients suffering from obstructive pulmonary diseases. This article provides a comprehensive review of the different promising pulmonary drug delivery technologies in the treatment of obstructive pulmonary diseases, particularly with regard to the treatment of asthma and chronic pulmonary diseases (COPD), which are increasing day by day due to increasing environmental pollution and its harmful and toxic contaminants. In the recent years, a better knowledge has been gained regarding the mechanism of action of glucocorticoids and how they suppress the chronic inflammation. New etiology has been brought into light regarding the inactivity of glucocorticoids in some patients having asthma and COPDs even though the inflammatory genes are triggered by similar molecules in both the diseases. This new knowledge has given a new platform to improve glucocorticoids and their resistance also how other combination therapy can be used for these diseases. It has also led to the quest for improving and developing other alternatives such as anti-leukotriene agents, muscarinic inhibitors, combination therapy, as well as biologic immune-modulators in the treatment of the different pulmonary diseases. Several new combinations of glucocorticoids are available in the global market for the use in pulmonary diseases especially asthma although their availability fluctuates between continents. There has been several studies done regarding the variation of effectiveness of the different inhaled glucocorticoids and hence it is important to take into consideration the different delivery systems and the methods which are used to treat the patients.
This article was published in European Journal of Pharmacology [© 2015 Elsevier] and the definite version is available at http://www.sciencedirect.com/science/article/pii/S0014299915301564 The article website is at: http://www.sciencedirect.com/science/journal/00142999/764/supp/C