Zara Sheikh
http://hdl.handle.net/10361/6763
2024-03-28T21:30:43Z
2024-03-28T21:30:43Z
In vivo measurement of the surface energy of human fingernail plates
Zara, Sheikh,
Murdan, Sudaxshina
Poojary, Chitranjan
Patel, Dilan R
Fernandes, João
Angarju
http://hdl.handle.net/10361/7090
2016-12-06T03:21:32Z
2012-03-01T00:00:00Z
In vivo measurement of the surface energy of human fingernail plates
Zara, Sheikh,; Murdan, Sudaxshina; Poojary, Chitranjan; Patel, Dilan R; Fernandes, João; Angarju
The surface energy of the human nail plate is expected to influence the adhesion of microorganisms (and subsequent colonization and infections) as well as that of medicines (and subsequent drug permeation) and of cosmetics. The aim of the study was therefore to measure the surface energy of nail plates in vivo. The surface energy of healthy human fingernails (untreated, hydrated and abraded) and of hoof membranes (often used as a model for the nail plate) was estimated from contact angle measurements of liquids (water, formamide, diiodomethane and glycerol) on the nail plate and subsequent computation using the Lifshitz–van der Waals/acid–base (LW-AB) approach. The surface energy of untreated fingernail plates was found to be 34 mJ m−2. Most of this total energy was from the apolar Lifshitz–van der Waals component. When the polar component of the surface energy was analysed, the electron donor component was considerably larger than the electron acceptor one. Hydrating the nail plate had no significant influence on the surface energy. In contrast, abrasion caused a small, but statistically significant increase in the apolar surface energy component. The surface energy of bovine hoof membrane was similar to that of the fingernail plate. We conclude that the human fingernail plate is a low-energy surface and that bovine hoof membranes may be used as a substitute for the nail plate in certain experiments.
This article was published in the International Journal of Cosmetic Science [© 2012 International Journal of Cosmetic Science] and the definite version is available at: http://discovery.ucl.ac.uk/1366902/1/nail_surface_energy_for_SOPwebsite.pdf
2012-03-01T00:00:00Z
Impact of cadmium exposure on human health with a focus on Bangladesh
Kabir, Eva Rahman
Sheikh, Zara
Khan, Tanisha Tabassum Sayka
http://hdl.handle.net/10361/7089
2016-12-04T06:51:23Z
2014-03-01T00:00:00Z
Impact of cadmium exposure on human health with a focus on Bangladesh
Kabir, Eva Rahman; Sheikh, Zara; Khan, Tanisha Tabassum Sayka
The environment in which we claim to “live” in has become a huge reservoir of toxic metals. Human
health is under constant risk of deterioration due to increasing chronic exposure of such metals that adversely affect
the quality of life of people. The deterioration of human health due to exposure to heavy metals has become a major
issue of concern worldwide. Although adverse health effects caused by heavy metals have been known for a long
time, exposure to heavy metals continues, and is even increasing in some parts of the world, particularly in less
developed countries, even though emissions have declined in most developed countries over the last 100 years. One
such heavy metal with a high toxicity found in the earth’s crust, associated with zinc, lead and copper ores is
cadmium. Exposure to cadmium has long been recognized as a health hazard, both in industry and in general
populations with high exposure. However, cadmium is toxic at very low exposure levels and has acute and chronic
effects on health and environment which is thus the cause of great concern. The parts of body that are potentially
affected from exposures to cadmium mainly involve the kidney, liver, lung, heart and bone. If one is exposed to
cadmium or cadmium compounds, a number of factors will determine whether or not the person will be affected.
These factors include not only dose and duration of contact, how he/she comes in contact with it but parameters such
as age, sex, diet, family traits, lifestyle, and state of health also tend to contribute to determine the extent of exposure
(ATSDR, 2012). The objective of this paper is to review available information on possible toxicities of cadmium on
human health. Our aim in this study was to identify the possible impacts of cadmium on human health, with the
ultimate goal of proposing the rationale for future quantitative research of cadmium in Bangladesh
This article was published in the European Journal of Toxicological Sciences [© 2014 European Journal of Toxicological Sciences] and the definite version is available at: https://goo.gl/v3JGjq
2014-03-01T00:00:00Z
Optimizing oral drug delivery using lipid based formulations
Sheikh, Zara
Nabila, Morshed
http://hdl.handle.net/10361/7088
2016-12-06T04:42:15Z
2014-01-01T00:00:00Z
Optimizing oral drug delivery using lipid based formulations
Sheikh, Zara; Nabila, Morshed
A great challenge facing the pharmaceutical scientists is transforming the new pharmacologically active lipophilic compounds that are poorly water soluble into orally administered medications with sufficient bioavailability. Lipid-based drug delivery systems has shown a great potential in the oral delivery of poorly water-soluble drugs, primarily for lipophilic drugs, with several successfully marketed products. Oral lipid-based formulations comprises of a broad range of oils, surfactants, and co-solvents. This review provides a comprehensive summary of the development, characterization, and utilization of oral lipid- based formulations, from both physicochemical and biopharmaceutical perspectives. The properties of the various lipid excipients are discussed and the criteria for selection of excipients for lipid-based formulations are identified. Finally the future prospects of this technique have been addressed to expand the utility of lipid based drug delivery systems.
This article was published in International Research Journal of Pharmacy [© 2014 International Research Journal of Pharmacy] and the definite version is available at: https://goo.gl/TTYiEn The Article's website is at: www.irjponline.com
2014-01-01T00:00:00Z
Phytochemical and hypoglycemic screening of seeds and peel of nephelium longan fruits
Ripa, Farhana
Dash, Pritesh Ranjan
Nesa, Mst. Luthfun
Sheikh, Zara
http://hdl.handle.net/10361/7087
2016-12-04T06:53:50Z
2015-12-01T00:00:00Z
Phytochemical and hypoglycemic screening of seeds and peel of nephelium longan fruits
Ripa, Farhana; Dash, Pritesh Ranjan; Nesa, Mst. Luthfun; Sheikh, Zara
Phytotherapy is considered to be lowest lethal or has no side effects in contrast to current allopathic medicines. The intention of the present investigation was to assess the therapeutic efficacy of Nephelium longan extract in an animal model of diabetes. So in this research we have performed phytochemical screening of methanolic extracts of peel (MNLP)
This article was published in the
International Journal of Biochemistry [©2015 International Journal of Biochemistry] and the definite version is available at: https://goo.gl/lRL2bC
2015-12-01T00:00:00Z