Mahmud Tareq Ibn Morshed
http://hdl.handle.net/10361/6761
2024-03-28T12:25:41Z
2024-03-28T12:25:41Z
Antioxidant, analgesic and CNS depressant effects of Synedrella nodiflora
Nahar, Laizuman,
Zahan, Ronok
Ibn Morshed, Mahmud Tareq
Haque, Anamul
Alam, Zahangir
Mosaddik, Ashik
http://hdl.handle.net/10361/7011
2016-12-04T08:23:40Z
2016-10-01T00:00:00Z
Antioxidant, analgesic and CNS depressant effects of Synedrella nodiflora
Nahar, Laizuman,; Zahan, Ronok; Ibn Morshed, Mahmud Tareq; Haque, Anamul; Alam, Zahangir; Mosaddik, Ashik
Synedrella nodiflora (L) Gaertn. belonging to the family Asteraceae contains steroids, reducing sugars, phenolic, flavonoids, saponins, tannins and triterpenoids. Therefore, this study is designed to investigate its antioxidant, analgesic and CNS depressant effects. Materials and Methods: The antioxidant activity of methanolic extract of S. nodiflora (SN) was determined using Folin Ciocalteu reagent, phosphomolybdenum method, free radical scavenging activity by 1,1-diphenyl-2-picryl-hydrazyl (DPPH) and the reducing power activity. Analgesic activity was done by acetic acid and formalin model and CNS depressant activity was measured by the hole cross and open field method. Results: The total phenols and total antioxidant capacity of SN was found to be 37.38 < 2.01 mg/g equivalent of gallic acid and 433.37 < 4.22 mg/gm equivalent of ascorbic acid. The percentage (%) scavenging of DPPH free radical was found to be concentration dependent and IC50 value was 125.89 < 2.23 µg/ml while the IC50 value of standard ascorbic acid was found to be 16.76 < 0.11 µg/ml. The reducing power of SN was found to be concentration dependent. Acetic acid and formalin models are peripherally acting analgesic methods. The oral administration of both doses (100 and 200 mg/kg b.wt.) of SN significantly (p<0.001) inhibited 40.06% and 61.83% writhing response induced by acetic acid whereas oral administration of the same doses of SN significantly (p<0.001) inhibited 56.96% and 62.60% itching response induced by formalin. The methanolic extract of SN, at the dose of 250 mg/kg and 500 mg/kg b.wt. produced significant (P<0.001) decrease of locomotion. This is the first report of CNS depressant activity of the plant.
This article was published in Pharmacognosy Journal [© 2012 Elsevier Ltd.] and the definite version is available at http://www.sciencedirect.com/science/article/pii/S0975357512800824 The article website is at: http://www.sciencedirect.com/science/journal/09753575/4
2016-10-01T00:00:00Z
Central nervous system depressant, analgesic and antidiarrheal effects of the seed extracts of Dimocarpus longan lour in rats
Ripa, Farhana Alam
Ibn Morshed, Mahmud Tareq
Afsana-Al-Sharmin
Papon, Shahed Bulbul
Islam, Md Rafiqul
Sheikh, Zara
http://hdl.handle.net/10361/6822
2016-12-04T11:04:40Z
Central nervous system depressant, analgesic and antidiarrheal effects of the seed extracts of Dimocarpus longan lour in rats
Ripa, Farhana Alam; Ibn Morshed, Mahmud Tareq; Afsana-Al-Sharmin; Papon, Shahed Bulbul; Islam, Md Rafiqul; Sheikh, Zara
Purpose: To assess the central nervous system (CNS) depressant, analgesic and antidiarrheal activities of the dried seed crude extracts of Dimocarpus longan Lour in rodents.
Methods: Selected pharmacological effects of the ethanol (ENLS), petroleum ether (PELS), chloroform (CHLS) and ethyl acetate (EALS) extracts of D. longan fruit seeds were investigated. CNS depressant activity was evaluated by open field and hole cross tests; analgesic activity by acetic acid-induced writhing test and formalin-induced licking test; and anti-diarrheal activity was assessed in castor oil and magnesium-induced diarrhea rat model. The extracts were given orally in a rat model at doses of 200 and 300 mg/kg body weight. Normal saline served as control in all experiment. In CNS depressant test, diazepam (1 mg/kg) was used as reference drug while indomethacin (10 mg/kg) and loperamide(2 mg/kg) were used as standard drugs in analgesic and antidiarrheal tests, respectively.
Results: In hole cross method, EALS showed the most effective depressant effect, viz, 1.17±0.17 for 200 mg/kg dose and 0.83±0.31 number of movements for 300 mg/kg dose after 120 min (p < 0.01), whereas in the open field test, all the extracts exhibited significant (p < 0.01) depressant effect in relation to positive control, diazepam. In acetic acid-induced pain test, PELS gave the lowest number of writhing (2.83±0.307) and the highest inhibition (88.45 %, 300 mg/kg dose) which was statistically significant. All the extracts also significantly (p < 0.01) suppressed licking activity in both phases of the formalin-induced licking test, in contrast to indomethacin. In the antidiarrheal tests, diarrheal suppression was highest at 300 mg/kg dose for all the extracts, compared with loperamide in both castor oil and magnesium sulphate induced diarrhea model.
Conclusion: The extracts of Dimocarpus longan tested demonstrated significant CNS depressant, analgesic and antidiarrheal activities in a rodent model.
This article was published in Tropical Journal of Pharmaceutical Research [© 2014 Tropical Journal of Pharmaceutical Research] and the definite version is available at: http://www.ajol.info/index.php/tjpr/article/view/101488/90672