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dc.contributor.authorChowdhury, Sabiha Mohammad
dc.contributor.authorPoddar, Saikat Kumar
dc.contributor.authorZaheen, Sarah
dc.contributor.authorNoor, Farah Ashrafi
dc.contributor.authorAhmed, Najneen
dc.contributor.authorHaque, Sanjana
dc.contributor.authorSukul, Abhijit
dc.contributor.authorSunjida, Sauda Binte
dc.contributor.authorMazumder, Md Mahabob Ullah
dc.contributor.authorAkbar, Nusrat
dc.identifier.citationChowdhury, S., Poddar, S. K., Zaheen, S., Noor, F. A., Ahmed, N., Haque, S., . . . Akbar, N. (2017). Phytochemical screening and evaluation of cytotoxic and hypoglycemic properties of mangifera indica peels. Asian Pacific Journal of Tropical Biomedicine, 7(1), 49-52. 10.1016/j.apjtb.2016.09.009en_US
dc.descriptionThis article was published in the Asian Pacific Journal of Tropical Biomedicine [© 2016 Hainan Medical University] and the definite version is available at : The Journal's website is at:
dc.description.abstractObjective To investigate the presence of different phytoconstituents in Mangifera indica (M. indica) peel and evaluate its cytotoxicity to Artemia salina and hypoglycemic potential in Swiss albino mice. Methods The methanolic extract of M. indica peel was used to determine the presence of phytoconstituents. Brine shrimp lethality bioassay method was followed to determine the cytotoxic potential of plant extract. In the case of hypoglycemic activity, oral administration of extract at 200 and 400 mg/kg and standard glibenclamide at 10 mg/kg was done, followed by determining the percentage of reduction of plasma glucose from the initial level. Results The methanolic extract of M. indica peel showed the presence of flavonoid, saponin, steroid, tannins, terpenoids, glycosides and alkaloids. In brine shrimp lethality bioassay, the LC50 of the extract and standard vincristine sulfate was found to be 2.04 and 0.41 μg/mL, respectively. After 90 and 150 min, the methanolic extract at 200 and 400 mg/kg showed prominent plasma glucose reduction of 13.95%, 22.48% and 14.16%, 26.18% respectively compared to standard glibenclamide showing 14.90% and 20.67% plasma glucose reduction. Conclusions This current research affirms prominent cytotoxic and moderate hypoglycemic potential of M. indica peel. Further bioactivity guided isolation of phytoconstituents and investigation on higher animals can lead to development of new drug molecules.en_US
dc.publisher© 2016 Hainan Medical Universityen_US
dc.subjectMangifera indicaen_US
dc.titlePhytochemical screening and evaluation of cytotoxic and hypoglycemic properties of Mangifera indica peelsen_US
dc.contributor.departmentDepartment of Pharmacy, BRAC University

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