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    Protection against shigellosis caused by shigella dysenteriae serotype 4 in Guinea pigs using escherichia albertii dm104 as a live vaccine candidate strain

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    Date
    2017-06
    Publisher
    © 2017 Akadémiai Kiadó
    Author
    Chowdhury, Fatema Moni
    Rahman, Mohammed Ziaur
    Sarkar, Md Murshed Hasan
    Rabbi, Fazle A.
    Khan, Sirajulislam
    Ahsan, Chowdhury Rafiqul
    Birkeland, Nils Kåre
    Metadata
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    URI
    http://hdl.handle.net/10361/9432
    Citation
    Chowdhury, F. M., Rahman, M. Z., Sarkar, M. M. H., Rabbi, F., Khan, S. I., Ahsan, C. R., & Birkeland, N. -. (2017). Protection against shigellosis caused by shigella dysenteriae serotype 4 in guinea pigs using escherichia albertii dm104 as a live vaccine candidate strain. Acta Microbiologica Et Immunologica Hungarica, 64(2), 151-164. 10.1556/030.64.2017.015
    Abstract
    Recently, we reported the induction of protective immunity by environmental Escherichia albertii strain DM104 against Shigella dysenteriae in Guinea pig model. In this study, we assessed three different immunization routes, such as intranasal, oral, and intrarectal routes, and revealed differences in immune responses by measuring both the serum IgG and mucosal IgA antibody titers. Protective efficacy of different routes of immunization was also determined by challenging immunized Guinea pigs against live S. dysenteriae. It was found that intranasal immunization showed promising results in terms of antibody response and protective efficacy. All these results reconfirm our previous findings and additionally point out that the intranasal immunization of the environmental E. albertii strain DM104 in Guinea pig model can be a better live vaccine candidate against shigellosis.
    Keywords
    Live; Shigella; Shigellosis; Vaccine
     
    Description
    This article was published in the Acta Microbiologica et Immunologica Hungarica [© 2017 Akadémiai Kiadó, Budapest] and the definite version is available at : http://doi.org/10.1556/030.64.2017.015 The Journal's website is at: http://akademiai.com/doi/abs/10.1556/030.64.2017.015
    Publisher Link
    http://akademiai.com/doi/abs/10.1556/030.64.2017.015
    DOI
    http://doi.org/10.1556/030.64.2017.015
    Department
    Department of Mathematics and Natural Sciences, BRAC University
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