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    • School of Pharmacy (PHR)
    • Bachelor of Pharmacy
    • Project report (Bachelor of Pharmacy)
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    Quantification of total phenol and flavonoid content, in vitro investigation of antioxidant activity and cytotoxic effect of the seed extract of piper nigrum linn (white pepper)

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    Date
    2016-02
    Publisher
    BRAC University
    Author
    Manzoor, Farzana
    Metadata
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    URI
    http://hdl.handle.net/10361/7625
    Abstract
    Piper nigrum Linn or pepper as more commonly known, is an essential everyday spice. Current study endeavours to assess the healing and medicinal properties that Piper nigrum exhibits, its role in traditional medicine and its application today. It is reported to possess antioxidant qualities that neutralize harmful “free radicals” in our body, many arguments are still being pointed towards its actual affectivity. In the present study, in vitro antioxidant activity of the seed extract of white pepper was evaluated by DPPH (2,2-diphenyl-1- picrylhydraziyl) free radical scavenging assay and total flavonoid and phenol content determination. In order to determine the cytotoxic effect of the extract, brine shrimp lethality test has been carried out where the LC50 value were determined and compared with the standard like vincristine sulphate. Our investigation indicates that the various fractions of the seed extract of white pepper contain high amount of phenol and flavonoid content with significant cytotoxic effect which may justify the traditional use of pepper and makes it as potential natural source in drug discovery and development.
    Keywords
    Piper nigrum; Antioxidants
     
    Description
    This project report is submitted in a partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2016
     
    Cataloged from PDF version of project report.
     
    Includes bibliographical references (page 49-50).
    Department
    Department of Pharmacy, BRAC University
    Collections
    • Project report (Bachelor of Pharmacy)

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