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    Effect of vitamin D, calcium and multiple micronutrients supplementation on lipid profile in pre-menopausal Bangladeshi garment factory workers with hypovitaminosis D

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    Date
    2014
    Publisher
    © 2014 International Center for Diarrhoeal Disease Research
    Author
    Islam, Md Zahirul
    Shamim, Abu Ahmed
    Viljakainen, Heli T
    Lamberg-Allardt, Christel
    Jehan, Atia H
    Khan, Habib Ullah
    Al-Arif, Ferdaus Ahmad
    Akhtaruzzaman, Mohammad
    Metadata
    Show full item record
    URI
    http://hdl.handle.net/10361/7590
    Citation
    Islam, M. Z., Shamim, A. A., Akhtaruzzaman, M., Kärkkäinen, M., & Lamberg-Allardt, C. (2014). Effect of vitamin D, calcium and multiple micronutrients supplementation on lipid profile in pre-menopausal bangladeshi garment factory workers with hypovitaminosis D. Journal of Health, Population and Nutrition, 32(4), 687-695.
    Abstract
    Elevated total cholesterol and low-density lipoprotein cholesterol in sera are both well-known risk factors of coronary heart disease. Adequate vitamin D status is important for optimal function of many organs and tissues of our body. There is continuing controversy about the effect of adequate vitamin D consumption on serum lipids and lipoproteins. The present study assessed the effect of vitamin D, calcium and multiple micronutrients supplementation on the lipid profile in Bangladeshi young female garment factory workers who have hypovitaminosis D. This placebo-controlled intervention trial conducted over a period of one year randomly assigned a total of 200 apparently healthy subjects aged 16-36 years to 4 groups. The subjects received daily supplements of 400 IU of vitamin D (VD group) or 400 IU of vitamin D+600 mg of calcium lactate (VD-Ca group), or multiple micronutrients with 400 IU of vitamin-D+600 mg of calcium lactate (MMN-VD-Ca group), or the group consuming placebo (PL group). Serum concentrations of lipid and lipoprotein, 25-hydroxyvitamin D (25OHD) and intact parathyroid hormone (iPTH) were measured at baseline and after one year of follow-up. No significant changes in the serum levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), LDL-C/HDL-C ratio were observed in the supplemented groups compared to the placebo group. Supplementation had a positive effect (p<0.05) on very low-density lipoprotein cholesterol (VLDL-C) and triacylglycerol (TAG). A negative correlation between changes in serum iPTH and HDL-C was observed, which indicated that subjects with the greatest decline in S-iPTH had the greatest increase in HDL-C. The results suggest that consumption of adequate vitamin D with calcium or MMN for one-year may have no impact on serum lipid profile in the subjects studied. Longer-term clinical trials with different doses of supplemental vitamin D are warranted in evaluating the effect of intervention.
    Keywords
    Female garment workers; HDL-cholesterol; LDL-cholesterol; Total cholesterol; Triacylglycerol; Vitamin D intervention; Bangladesh
     
    Description
    This article was published in the Journal of Health, Population and Nutrition [© 2014 International Center for Diarrhoeal Disease Research] and The Journal's website is at: https://www.ncbi.nlm.nih.gov/pubmed/25895202
    Publisher Link
    https://www.ncbi.nlm.nih.gov/pubmed/25895202
    Department
    James P Grant School of Public Health, BRAC University
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