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dc.contributor.authorZaman, Aubhishek M.
dc.contributor.authorRazzaque, Samsad
dc.identifier.citationZaman, A., & Razzaque, S. (2013). Designing novel antibacterials: Application of omics science. [Yeni antibiyotikler tasarlamak: "omik" bilimin uygulanmasi{dotless}] Klimik Dergisi, 26(1), 2-8. doi:10.5152/kd.2013.02en_US
dc.descriptionThis article was published in Klimik Dergisi [ © 2013 Klimik Dergisi ] and the definite version is available at : The Journal's website is at:
dc.description.abstractAntibacterials are agents that act against pernicious bacterial pathogens by killing or inactivating them. At present, designing antibacterials have been assisted greatly by omics sciences-genomics, proteomics, metabolomics and interactomics. This review discusses different aspects of the omics sciences in simple to complex hierarchies. From the simplest of sequence analysis to more complex on the pyramid -structural, functional and interactional analysisall comprises the grand ambit of omics science. Sequence comparison can reveal novel information about drug resistance in the bacteria and thus can be of momentous significance for designing improved antibacterials. On the other hand, sequence characterization of the host protein can lead to production of effective antibiotic synthetically. Nowadays, structure based molecular designing, using computational docking techniques, has become a widely accepted routine work in drug designing processes. Moreover, new high-throughput data from microarray expression, protein-protein interaction assay are opening up a new vista for detecting more and more drug targets. Extensive focus put on to understand host-pathogen interaction on systems level has greatly accelerated the process of designing effective antibacterials against tuberculosis and many such complex diseases. Summarizing, this review exemplifies various different ways how increasingly omics science is transforming the paradigm of discovering novel antibacterials; omics approach is all set to speed up the process and bring down the expenses of the antibacterials even more in time to come.en_US
dc.publisher© 2013 AVES Ibrahim Karaen_US
dc.subjectAnti-bacterial agentsen_US
dc.subjectComparative genomicsen_US
dc.subjectOmics scienceen_US
dc.subjectStructural and functional omicsen_US
dc.titleDesigning novel antibacterials: application of omics scienceen_US
dc.title.alternative[Yeni antibiyotikler tasarlamak: "omik" bilimin uygulanmasi{dotless}]
dc.contributor.departmentDepartment of Mathematics and Natural Sciences, BRAC University

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