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    In vitro study on interaction of ketotifen fumarate with metformin hydrochloride

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    Date
    2011
    Publisher
    © 2011 Latin American Journal of Pharmacy
    Author
    Sayeed, Mohammed Aktar
    Hasan, S. M. Raquibul
    Rana, Md Sohel
    Metadata
    Show full item record
    URI
    http://hdl.handle.net/10361/7157
    Citation
    Sayeed, M. A., Hasan, S. M. R., & Rana, M. S. (2011). In vitro study on interaction of ketotifen fumarate with metformin hydrochloride. Latin American Journal of Pharmacy, 30(1), 189
    Abstract
    The present study was designed to study the in vitro interaction of ketotifen fumarate and metformin hydrochloride in aqueous media at different pH values using Job's continuous-variation analysis and Ardon's spectrophotomeric measurement. Job's analysis indicated the formation of 1:1 complex between ketotifen fumarate and metformin hydrochloride at the studied pH values. On the other hand, the values of stability constants (between negative values and 1), as calculated from Ardon's plot, mean that the formation of complex due to interaction between the drugs is readily dissociable. Thus the findings of the study suggest that both drugs can be safely co-administered. However, further studies involving animal models are needed to ascertain the exact nature of interaction between them in vivo.
    Keywords
    Ardon's mehod; Job's method; Ketotifen; Metformin; Stability constant
     
    Description
    This article was published in Latin American Journal of Pharmacy [© 2011 Latin American Journal of Pharmacy] and the definite version is available at: https://goo.gl/XOJ7tm
    Publisher Link
    https://goo.gl/XOJ7tm
    Department
    Department of Pharmacy, BRAC University
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