• Login
    • Library Home
    View Item 
    •   BracU IR
    • BracU Faculty Publications
    • Ekramul Haque
    • Article
    • View Item
    •   BracU IR
    • BracU Faculty Publications
    • Ekramul Haque
    • Article
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Antidiarrheal, antioxidant and antimicrobial activities of the musa sapientum seed

    Thumbnail
    Date
    2011
    Publisher
    © 2011, Avicenna Journal of Medical Biotechnology.
    Author
    Hossain, M Sarowar
    Alam, M Badrul
    Asadujjaman, M
    Zahan, Ronok
    Islam, M Monirul
    Mazumder, M Ehsanul H
    Haque, Md Ekramul
    Metadata
    Show full item record
    URI
    http://hdl.handle.net/10361/7154
    Citation
    Sarowar Hossain, M., Badrul Alam, M., Asadujjaman, M., Zahan, R., Monirul Islam, M., Mazumder, M. E. H., & Haque, M. E. (2011). Antidiarrheal, antioxidant and antimicrobial activities of the musa sapientum seed. Avicenna Journal of Medical Biotechnology, 3(2), 95-105
    Abstract
    Musa sapientum (M.sapientum) commonly known as 'banana' is widely used in Bangladeshi folk medicine for the treatment of various ailments including diarrhea. Hence, the present study was designed to investigate antidiarrheal, antioxidant and antibacterial potential of the methanolic extract of M.sapientum seed (MMSS). The extract was studied for antidiarrheal property using castor oil and magnesium sulfate induced diarrheal model and charcoal induced gastrointestinal motility test in mice. Total phenolic and flavonoids content, total antioxidant activity, scavenging of 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical, as well as nitric oxide (NO) and assessment of reducing power were used to evaluate antioxidant potential of MMSS. In addition, disc diffusion methods were used for antibacterial assay using various diarrheal induced bacterial strains. At the doses of 100 and 200 mg/kg body weight, the extract reduced the frequency and severity of diarrhea in test animals throughout the study period. At the same doses, the extracts significantly (p<0.001) delayed the intestinal transit of charcoal meal in test animals as compared to the control. In DPPH and NO scavenging method, MMSS showed good antioxidant potentiality in a dose dependent manner with the IC50 value of 12.32±0.33 μg/ml and 18.96±1.01 μg/ml, respectively with a significant (p<0.001) good reducing power. The extract also displayed strong antibacterial effect against when tested against Escherichia coli, Shigella dysenteriae, and Pseudomonas aeruginosa. Altogether, these results suggest that the MMSS could be used as a potential antidiarrheal agent along with its antioxidant and antibacterial potentiality.
    Keywords
    Antibacterial agents; Diarrhea; Free radicals; Musa sapientum
     
    Description
    This article was published in Avicenna Journal of Medical Biotechnology [© 2011, Avicenna Journal of Medical Biotechnology] and the definite version is available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3558179/
    Publisher Link
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3558179/
    Department
    Department of Pharmacy, BRAC University
    Collections
    • Article

    Copyright © 2008-2019 Ayesha Abed Library, Brac University 
    Contact Us | Send Feedback
     

     

    Policy Guidelines

    • BracU Policy
    • Publisher Policy

    Browse

    All of BracU Institutional RepositoryCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

    My Account

    LoginRegister

    Statistics

    View Usage Statistics

    Copyright © 2008-2019 Ayesha Abed Library, Brac University 
    Contact Us | Send Feedback