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    In vitro free radical scavenging and thrombolytic activities of Bangladeshi aquatic plant Aponogeton undulatus Roxb

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    Date
    2011
    Publisher
    © IDOSI Publications, 2011
    Author
    Chowdhury, Nargis S
    Alam, Md. Badrul
    Haque, A S M Tanbirul
    Zahan, Ronok
    Ehsanul, M
    Mazumder, Haque
    Haque, M Ekramul
    Metadata
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    URI
    http://hdl.handle.net/10361/7133
    Citation
    Chowdhury, N. S., Alam, M. B., Tanbirul Haque, A. S. M., Zahan, R., Mazumder, M. E. H., & Haque, M. E. (2011). In vitro free radical scavenging and thrombolytic activities of bangladeshi aquatic plant aponogeton undulatus roxb. Global Journal of Pharmacology, 5(1), 27-32
    Abstract
    Investigation with the crude methanolic extract of Aponogeton undulatus was carried out to evaluate its possible antioxidant and thrombolysis activity. In DPPH free radical scavenging assay, the extract exhibited potent antioxidant activity with a IC50 values of 2.43±1.06 μg/ml while in ascorbic acid, the value become 50 2.14±0.11 μg/ml. In thrombolytic activity using in vitro clot lysis assay method, the crude methanolic extract was found to have significant (p<0.001) thrombolytic activity at a dose of 10 mg/ml with a miximum effect of 20.23±1.56% while the standard streptokinase showed 46.13±3.87%. The extract was also investigated for its antibacterial and toxic potentiality using agar diffusion and Brine Shrimp lethality bioassay, respectively. The highest antibacterial effect was shown against Bacillus cereus (zone of inhibition 12±0.65 mm) followed by Escherichia coli (zone of inhibition 10±0.71 mm). In this bioassay the extract showed significant toxicity to Brine Shrimp nauplii with the LC50 value of 2.24±0.98 μg/ml. The study clearly indicated that the extract 50 possesses good antioxidant and thromolytic activity along with broad spectrum antibacterial and toxic potentiality.
    Keywords
    Free radical; Thrombolysis; Toxicity
     
    Description
    This article was published in Global Journal of Pharmacology [© IDOSI Publications, 2011] and the definite version is available at: https://idosi.org/gjp/5(1)11/6.pdf
    Publisher Link
    https://idosi.org/gjp/5(1)11/6.pdf
    Department
    Department of Pharmacy, BRAC University
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