• Login
    • Library Home
    View Item 
    •   BracU IR
    • BracU Faculty Publications
    • Ronok Zahan
    • Article
    • View Item
    •   BracU IR
    • BracU Faculty Publications
    • Ronok Zahan
    • Article
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Anticancer activity of alangium salvifolium flower in ehrlich ascites carcinoma bearing mice

    Thumbnail
    Date
    2011-03
    Publisher
    © 2011 Academic Journals Inc.
    Author
    Zahan, Ronok
    Alam, Md. Badrul
    Islam, Saiful
    S. Chowdhury, Nargis
    B. Hosain, Salman
    Mosaddik, Ashik
    Jesmin, Mele
    Haq, M. Ekramul
    Metadata
    Show full item record
    URI
    http://hdl.handle.net/10361/7121
    Citation
    Zahan, R., Badrul Alam, M., Saiful Islam, M., Sarker, G. C., Chowdhury, N. S., Hosain, S. B., . . . Ekramul Haque, M. (2011). Anticancer activity of alangium salvifolium flower in ehrlich ascites carcinoma bearing mice. International Journal of Cancer Research, 7(3), 254-262. doi:10.3923/ijcr.2011.254.262
    Abstract
    The research study was conducted to determine the antitumor effect of the flower of Alangium salvifolium (crude extract and diethylether fractions) against Ehrlich Ascites Carcinoma (EAC) in mice at the doses of 10 mg kg-1 body weight intraperitoneally. Extract/fractions was administered for nine consecutive days. Twenty-four hours of last dose and 18 h of fasting, the mice were sacrificed and antitumor effect was assessed by evaluating tumor volume, viable and nonviable tumor cell count, tumor weight and hematological parameters of EAC bearing host. Significant (p<0.001) increases of survival times 30±0.96 and 25±0.40 days for crude extract and diethylether fraction of the A. salvifolium (10 mg kg-1) treated tumor bearing mice, respectively were confirmed with respect to the control group (20±0.13 days). The extract/fraction also decreased the body weight of the EAC tumor bearing mice. Hematological studies reveal that the heamoglobin (Hb) content was decreased in EAC treated mice whereas restoration to near normal levels was observed in extract treated animals. There was a significant (p<0.001) decrease in RBC count and increase in WBC counts in extract/fraction treated animals when compared to EAC treated animals. From the result it was showed that the extract has significant anticancer activity and that is comparable to that of Bleomycin.
    Keywords
    Alangium salvifolium; Anticancer; Ehrlich ascites carcinoma; Hematological profile; Mean survival time
     
    Description
    This article was published in International Journal of Cancer Research [© 2011 Academic Journals Inc.] and the definite version is available at : http://scialert.net/qredirect.php?doi=ijcr.2011.254.262&linkid=pdf
    Publisher Link
    http://scialert.net/qredirect.php?doi=ijcr.2011.254.262&linkid=pdf
    DOI
    http://doi.org/10.3923/ijcr.2011.254.262
    Department
    Department of Pharmacy, BRAC University
    Collections
    • Article
    • Article
    • Article
    • Article

    Copyright © 2008-2019 Ayesha Abed Library, Brac University 
    Contact Us | Send Feedback
     

     

    Policy Guidelines

    • BracU Policy
    • Publisher Policy

    Browse

    All of BracU Institutional RepositoryCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

    My Account

    LoginRegister

    Statistics

    View Usage Statistics

    Copyright © 2008-2019 Ayesha Abed Library, Brac University 
    Contact Us | Send Feedback