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    Characterization of phytoconstituents and potential bioactivity of Annona reticulata L. leaf extract

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    Date
    2016
    Publisher
    © 2016 Journal of Pharmacognosy and Phytochemistry
    Author
    Shahriar, Mohammad
    Khair, Nishat Zareen
    Sheikh, Zara
    Chowdhury, Sayeeda Fahmee
    Kamruzzaman, Md.
    Bakhtiar, Md. Shawkatul Islam
    Chisty, Sharmin Jahan
    Metadata
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    URI
    http://hdl.handle.net/10361/7085
    Citation
    1. Shahriar M, Khair N.Z, Sheikh Z, Chowdhury S.F et al (2016). Characterization of phytoconstituents and potential bioactivity of Annona reticulata L. leaf extract. Journal of Pharmacognosy and Phytochemistry, 5(1): 42-45
    Abstract
    Annona reticulata (Annonaceae) is known as atafol in Bangla and custard apple in English is an important medicinal plant. It has been used traditionally in diarrhea, dysentery, cold, as abortifacient, insecticidal drug etc. In this present study, the leaf extracts of Annona reticulata were subjected to evaluation of the thrombolytic activity was assessed by using human erythrocyte and the results were compared with standard streptokinase (SK). The chloroform extract showed 36.82% clot lysis as compared to 93.79% clot lysis produced by standard streptokinase. The leaf extracts of Annona reticulata were subjected to evaluation of the membrane stabilizing activity by using human erythrocyte and the results were compared with standard anti-inflammatory drug, acetyl salicylic acid (ASA). In vitro membrane stabilizing activity for hypotonic solution induced haemolysis, the chloroform extract inhibited 75.15% haemolysis of RBCs as compared to 72.99% produced by acetyl salicylic acid (ASA) and during heat induced condition different organic soluble materials of Annona reticulata demonstrated methanol, ethanol and chloroform extract showed 68.81%, 72.06% and 78.17% inhibition of RBC hemolysis respectively whereas standard acetylsalicylic acid showed 70.87% inhibition of RBC haemolysis.
    Keywords
    Annona reticulate; Leaf extract; Phytoconstituents; Membrane stabilizing; Thrombolytic activity
     
    Description
    This article was published in the Journal of Pharmacognosy and Phytochemistry [©2016 Journal of Pharmacognosy and Phytochemistry]
    Department
    Department of Pharmacy, BRAC University
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