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    Free radical-scavenging activities and cytoprotective effect of polyphenol-rich ethyl acetate fraction of guava (Psidium cattleianum) leaves on H2O2-treated HepG2 cell

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    Date
    2013-12
    Publisher
    © 2013 Springer Link
    Author
    Mosaddik, Ashik
    Moon, Jeong Yong
    Lee, Sarah
    Jeong, Seongweon
    Kim, Jong-Chan
    Ahn, Kwang Seok
    Cho, Somi Kim
    Metadata
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    URI
    http://hdl.handle.net/10361/6939
    Citation
    Moon, J. Y., Lee, S., Jeong, S., Kim, J. -., Ahn, K. S., Mosaddik, A., & Cho, S. K. (2013). Free radical-scavenging activities and cytoprotective effect of polyphenol-rich ethyl acetate fraction of guava (psidium cattleianum) leaves on H2O2-treated HepG2 cell. Journal of the Korean Society for Applied Biological Chemistry, 56(6), 687-694. doi:10.1007/s13765-013-3156-z
    Abstract
    Total phenolic contents of different fractions of the Psidium cattleianum leaf extract and their antioxidant capacity against several free radicals were examined. Protective effect of the ethyl acetate fraction (EAF) on H2O2-induced DNA damage in HepG2 cells were also evaluated, and the phytochemical profile of EAF was analyzed using tandem mass spectrometry. EAF derived from the 80% methanol extract of the leaf contained a remarkable amount of polyphenol and showed high levels of DPPH and alkyl radical scavenging activity, promoted cell viability, and protected against H2O2-induced DNA damage in HepG2 cells. Phytochemical analysis revealed that the major components in the EAF included quercetin monoglycoside, phloridizin, quercetin 3-diglycoside, quercetin-3-glucuronide, 2,6-dihydroxy-3,5-dimethyl-4-glucopyranosylbenzophenone, phenolic acid, guaijaverin, and naringin. The present study suggests possible synergistic or competitive antioxidant action of the major compounds of cattley guava leaf on H2O2-induced DNA damage in HepG2 cells. These results indicate that the ethyl acetate fraction of the guava leaf could be used as a potential source of natural antioxidants, and these findings will facilitate the utilization of guava leaf as a source of functional food.
    Keywords
    Antioxidants; Free radical; HepG2; Guava leaf; Polyphenol
     
    Description
    This article was published in Journal of the Korean Society for Applied Biological Chemistry [© 2013 Springer Link] and the definite version is available at: http://link.springer.com/article/10.1007/s13765-013-3156-z The article website is at: http://link.springer.com/journal/13765
    Publisher Link
    http://link.springer.com/article/10.1007/s13765-013-3156-z#article-dates-history
    Department
    Department of Pharmacy, BRAC University
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