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dc.contributor.authorZahan, Ronok
dc.contributor.authorKabir, Seiina
dc.contributor.authorMosaddik, Ashik
dc.contributor.authorChowdhury, Abdullah Mohammad Sarwaruddin
dc.contributor.authorHasan, Choudhury Mahmood
dc.contributor.authorRashid, Mohammad Abdur
dc.identifier.citationKabir, S., Zahan, R., Mosaddik, A., Chowdhury, A. M. S., Hasan, C. M., & Rashid, M. A. (2013). Antioxidant and antitumor activities of polyalthia simiarum (buch.-ham. ex hook. F. & thomson) hook. F. & thomson. [Polyalthia simiarum (Buch.-Ham. ex Hook. F. & Thomson) Hook. F. & Thomson'un antioksidan ve antitümör aktivitesi] Turkish Journal of Pharmaceutical Sciences, 10(3), 405-413.en_US
dc.descriptionThis article was published in Turkish Journal of Pharmaceutical Sciences [© 2013 Turkish Journal of Pharmaceutical Sciences] and the definite version is available at: The article website is at: http://journal.eczakademi.orgen_US
dc.description.abstractThe present study has been designed to investigate the antioxidant and antitumor activities of ethyl acetate (EA) extract of stem bark of Polyalthia simiarum (Annonaceae). Antioxidant potential of the EA extract was evaluated in vitro by DPPH (1,l-diphenyl-2-picrylhydrazyl) scavenging assay method. The EA extract showed free radical scavenging activity with IC50 value of 24.08 ± 0.30 fig/mL. The antitumor activity of the extract was determined against Ehrlich ascites carcinoma (EAC) in mice at 25 mg/kg and 5Í) mg/kg body weight intraperitoneal. Significant (p<0.001) increase of survival time by 25 ± 0.57 and 27 ± 0.40 days by the EA extract treated tumor bearing mice was confirmed with respect to the control group (22 ± 0.12 days). Hematological studies revealed that the hemoglobin (Hb) content was decreased in EAC treated mice whereas restoration to close to normal levels was observed in extract treated animals. There was a significant (p<0.001) decrease in RBC and increase in WBC counts in extract treated animals when compared to EAC affected animals. Therefore, the EA extract of P. simiarum was capable to exhibit moderate antioxidant and antitumor activities. This is the first report of antioxidant and antitumor potential of P. simiarum.en_US
dc.publisher© 2013 Turkish Journal of Pharmaceutical Sciencesen_US
dc.subjectAntineoplastic agentsen_US
dc.subjectEthyl acetateen_US
dc.subjectBody weighten_US
dc.subjectMice as laboratory animalsen_US
dc.titleAntioxidant and antitumor activities of Polyalthia simiarum (Buch.-Ham. ex Hook. F. & Thomson) Hook. F. & Thomsonen_US
dc.contributor.departmentDepartment of Pharmacy, BRAC University

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