• Login
    • Library Home
    View Item 
    •   BracU IR
    • BracU Faculty Publications
    • Laizuman Nahar
    • Article
    • View Item
    •   BracU IR
    • BracU Faculty Publications
    • Laizuman Nahar
    • Article
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Comparative study of antidiabetic activity of Cajanus cajan and Tamarindus indica in alloxan-induced diabetic mice with a reference to in vitro antioxidant activity

    Thumbnail
    Publisher
    © 2014 Pharmacognosy Network Worldwide
    Author
    Nahar, Laizuman
    Haque, Ekramul
    Nasrin, Fatema
    Mosaddik, Ashik
    Zahan, Ronok
    Haque, Anamul
    Metadata
    Show full item record
    URI
    http://hdl.handle.net/10361/6825
    Citation
    Nahar, L., Nasrin, F., Zahan, R., Haque, A., Haque, E., & Mosaddik, A. (2014). Comparative study of antidiabetic activity of cajanus cajan and tamarindus indica in alloxan-induced diabetic mice with a reference to in vitro antioxidant activity. Pharmacognosy Research, 6(2), 180-187. doi:10.4103/0974-8490.129043
    Abstract
    Oxidative stress not only develops complications in diabetic (type 1 and type 2) but also contributes to beta cell destruction in type 2 diabetes in insulin resistance hyperglycemia. Glucose control plays an important role in the pro-oxidant/antioxidant balance. Some antidiabetic agents may by themselves have antioxidant properties independently of their role on glucose control. Objective: The present investigation draws a comparison of the protective antioxidant activity, total phenol content and the antihyperglycemic activity of the methanolic extract of Cajanus cajan root (MCC) and Tamarindus indica seeds (MTI). Materials and Methods: Antidiabetic potentials of the plant extracts were evaluated in alloxan-induced diabetic Swiss albino mice. The plant extracts at the doses of 200 and 400 mg/kg body weight was orally administered for glucose tolerance test during 1-hour study and hypoglycemic effect during 5-day study period in comparison with reference drug Metformin HCl (50 mg/kg). In vitro antioxidant potential of MCC and MTI was investigated by using 1, 1- diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging activity at 517 nm. Total phenolic content, total antioxidant capacity and reducing power activity was also assayed. Results: There was a significant decrease in fasting serum glucose level (P < 0.001), reduction in blood glucose level (P < 0.001) in 5-days study, observed in the alloxan-induced diabetic mice. The reduction efficacy of blood glucose level of both the extracts is proportional to their dose but MCC is more potent than MTI. Antioxidant study and quantification of phenolic compound of both the extracts revealed that they have high antioxidant capacity. Conclusion: These studies showed that MCC and MTI have both hypoglycemic and antioxidant potential but MCC is more potent than MTI. The present study suggests that both MCC and MTI could be used in managing oxidative stress.
    Keywords
    Alloxan; Antioxidant activity; Diphenyl-2-picrylhydrazyl; Hyperglycemia; Metformin; Hydrochloride; Oxidative stress
     
    Description
    This article was published in Pharmacognosy Research [© 2014 Pharmacognosy Network Worldwide] and the definite version is available at: http: http://www.phcogres.com/article.asp?issn=0974-8490;year=2014;volume=6;issue=2;spage=180;epage=187;aulast=Nahar The article website is at: http://www.phcogres.com
    Publisher Link
    https://goo.gl/7H41vC
    DOI
    10.4103/0974-8490.129043
    Department
    Department of Pharmacy, BRAC University
    Collections
    • Article
    • Article
    • Article

    Copyright © 2008-2019 Ayesha Abed Library, Brac University 
    Contact Us | Send Feedback
     

     

    Policy Guidelines

    • BracU Policy
    • Publisher Policy

    Browse

    All of BracU Institutional RepositoryCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

    My Account

    LoginRegister

    Statistics

    View Usage Statistics

    Copyright © 2008-2019 Ayesha Abed Library, Brac University 
    Contact Us | Send Feedback