BRAC University Institutional Repository

Evaluation of analgesic, antipyretic, hypoglycemic and CNS depressant activity of 2-bromopopylamine hydrobromide, 3-bromopopyl ammonium bromide, ortho-amino aniline and benzimidazole-2-thiol in animal model

Show simple item record

dc.contributor.author Md. Hamiduzzaman
dc.contributor.author Dey, Avijit
dc.contributor.author Mannan, Sultana Juhara
dc.contributor.author Rahman, S. M. Abdur
dc.date.accessioned 2016-11-14T10:04:52Z
dc.date.available 2016-11-14T10:04:52Z
dc.date.copyright 2014
dc.identifier.citation Hamiduzzaman, M., Mannan, S. J., Dey, A., & Abdur Rahman, S. M. (2014). Evaluation of analgesic, antipyretic, hypoglycemic and CNS depressant activity of 2-bromopopylamine hydrobromide, 3-bromopopyl ammonium bromide, ortho-amino aniline and benzimidazole-2-thiol in animal model. Der Pharmacia Lettre, 6(1), 47-53.
dc.identifier.issn 09755071
dc.identifier.uri http://hdl.handle.net/10361/6821
dc.description.abstract Synthetic compounds are encompassing the major ther apeutic classes of drugs which resemblance to the n atural or existing therapeutically active compounds. Herewith four synthetic compounds i.e. 2-bromopropylamine hydrobromide, 3-bromopropyl ammonium bromide, ortho -amino aniline and benzimidazole-2-thiol were subje cted for analgesic, antipyretic, hypoglycemic and CNS de pressant activity in mice and rat model following s tandard protocol. Among the four supplied synthetic compoun ds, benzimidazole-2-thiol and 3-bromopropyl ammoniu m bromide at a dose of 50 mg/kg body wt revealed sign ificant analgesic activity with 37.85% and 42.85% i nhibition of writhing (P value < 0.001 in both cases). None of t he test samples showed antipyretic activity in rat model at a dose of 50 mg/kg body wt in comparable with standard ant ipyretic drug Paracetamol. On the other hand benzim idazole- 2-thiol reduced blood glucose level with respect to standard drug Glibenclamide having P value 0.00082 and 3- bromopropyl ammonium bromide lengthened the Na-phen obarbitone induced sleeping time having the P value 0.0009 which was statistically significant.
dc.publisher © 2014 Der Pharmacia Lettre
dc.relation.uri http://scholarsresearchlibrary.com/dpl-vol6-iss1/DPL-2014-6-1-47-53.pdf
dc.subject Analgesic activity
dc.subject Antipyretic activity
dc.subject CNS depressant activity
dc.subject Hypoglycemic activity
dc.subject Synthetic compounds
dc.title Evaluation of analgesic, antipyretic, hypoglycemic and CNS depressant activity of 2-bromopopylamine hydrobromide, 3-bromopopyl ammonium bromide, ortho-amino aniline and benzimidazole-2-thiol in animal model en_US
dc.type Article en_US
dc.description.version Published
dc.contributor.department Department of Pharmacy, BRAC University


Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

Policy Guidelines

Search BRACU Repository


Advanced Search

Browse

My Account

Statistics