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    A new cytotoxic diterpenoid glycoside from the leaves of Blumea lacera and its effects on apoptosis and cell cycle

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    Publisher
    © 2016 Taylor and Francis Ltd.
    Author
    Akter, Raushanara A.
    Uddin, Shaikh J.
    Tiralongo, Joe
    Grice, Darren
    Tiralongo, Evelin
    Metadata
    Show full item record
    URI
    http://hdl.handle.net/10361/6797
    Citation
    Akter, R., Uddin, S. J., Tiralongo, J., Grice, I. D., & Tiralongo, E. (2016). A new cytotoxic diterpenoid glycoside from the leaves of blumea lacera and its effects on apoptosis and cell cycle. Natural Product Research, 30(23), 2688-2693. doi:10.1080/14786419.2016.1146887
    Abstract
    A new diterpenoid glycoside, 6E,10E,14Z-(3S)-17-hydroxygeranyllinalool-17-O-β-d-glucopyranosyl-(1 → 2)-[α-l-rhamnopyranosyl-(1 → 6)]-β-d-glucopyranoside (1) together with the known diterpenoid glycoside (2) and two known flavonoid glycosides (3, 4) were isolated from the methanol extract of Blumea lacera leaves. The structures were determined by the interpretation of their spectroscopic data and comparison with the literature. All compounds were isolated for the first time from B. lacera and evaluated for their cytotoxic activity. Only the new compound (1) showed strong cytotoxic activity with the lowest IC50 value (8.3 μM) being displayed against MCF-7 breast cancer cells. In apoptosis and cell cycle analysis, 1 revealed strong apoptotic activity against MCF-7 cells (45.5% AV+/PI−) after 24 h, but showed no arresting of any of the cell cycle phases in MCF-7. © 2016 Informa UK Limited, trading as Taylor & Francis Group.
    Keywords
    Blumea lacera leaves; Cell cycle analysis; Cytotoxicity; Diterpenoid glycoside; Flavonoid glycoside
     
    Description
    This article was published in Natural Product Research [© 2016 Taylor and Francis Ltd.] and the definite version is available at: https://goo.gl/ba4EOj
    Publisher Link
    https://goo.gl/ba4EOj
    DOI
    10.1080/14786419.2016.1146887
    Department
    Department of Pharmacy, BRAC University
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