This comparative study was carried out to investigate the presence of antibiotic sensitive and resistant bacteria in different environmental samples of Bangladesh with specific clinical strain obtained from ICDDR, B .The environmental samples were isolated from the month April 2014 to September 2014 from different locations of Dhaka city to perceive the propensity of the environmental isolates to develop antibiotic resistance at different time periods of a year. The bacterial isolates were identified on the basis of standard cultural, morphological and biochemical characteristics. Antibiogram was done to identify the antibiotic susceptibility of the isolates according to CLSI guideline. The result of this study indicated that significant number of the environmental isolates has become resistant to the tested antibiotics, and some of them have become multi-resistant to these therapeutic agents whereas all the clinical isolates showed the opposite result. The study helps to predict the future emergence and guide the development of strategies to counteract this resistance. Therefore periodic and comprehensive survey of antibiotic resistance in the environmental bacteria is required.
