• Login
    • Library Home
    View Item 
    •   BracU IR
    • School of Data and Sciences (SDS)
    • Department of Mathematics and Natural Sciences (MNS)
    • Master of Science in Biotechnology
    • Thesis (Master of Science in Biotechnology)
    • View Item
    •   BracU IR
    • School of Data and Sciences (SDS)
    • Department of Mathematics and Natural Sciences (MNS)
    • Master of Science in Biotechnology
    • Thesis (Master of Science in Biotechnology)
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Development of Immune response in different age groups of children from Birth to 2 years of age

    Thumbnail
    View/Open
    Nowrin.pdf (22.39Mb)
    Date
    2011-12
    Publisher
    BRAC University
    Author
    Nowshaba, Nowrin
    Metadata
    Show full item record
    URI
    http://hdl.handle.net/10361/1667
    Abstract
    Human neonates are markedly more susceptible to infection than are older children or adults. This increased susceptibility is generally believed to be due to immaturity of the immune system to combat pathogens in both quantitative and qualitative terms. Therefore, it is important to understand the pattern of immune response present at early age in children. This study was conducted to observe the development of the immune system in newborns and infants of different ages. For this purpose, 50 participants were selected and divided into five groups as newborns, 6, 12 , 18 and 24 months of age (for each group, the sample size was n=10). The T cell proliferation response to tetanus toxoid (TT) was considerably low in newborns than in children of other age groups whereas differences in PHA response were not significantly different. The distribution of T-cell and B-cell specific surface proteins clusters of differentiation (CD) markers on lymphocytes of participant newborns and infants were analyzed, The percentage of CD3+ T cells were significantly less in newborns than in children 6 months (P< 0.0001), l2 months (P< 0.0001),18 months (P= 0.001) and 24 months (P< 0.0001) old children while age-dependent gradual decrease was seen in % of CD3+CD4+ (T helper cells) and % of CD3+CD8+ (cytotoxic T cells) and their ratio (CD4+/CD8+) where % of CD 19+ B cells were much elevated in older age groups than in newborns. Cholera toxin (CT) of Vibrio cholerae specific plasma IgA response was found notably low in newborns than in 6 months (P= 0.0003), 12 months (P= 0.0001), 18 months (P= 0.0001), and 24 months (P= 0.0001) aged children. When compared with 6 month old infants with those that were 12 months (P= 0.02), 18 months (P= 0.029), and 24 months of age (P= 0.007) the CT- IgG response was elevated in 24 months children than newborns (P< 0.0001) and 6 months infants (P= 0.03). Similarly the IgA and IgG response was seen against the heat labile toxin (LT) of Escherichia coll. Significantly high tetanus toxoid (TT) specific IgG response was seen in newborns than in those 6 months (P= 0.04), 12 months (P= 0.02), 18 months (P= 0.007) and 24 months (P= 0.02) of age. In contrast, measles virus specific IgG was distinctly high in 6 months (P= 0.001), 12 months (P= 0.03), 18 months (P=0.009) and 24 months (P= 0.015) old children when compared to newborns using cord blood analyses. A base line level vibriocidal antibody response was observed in the study children. The fecal IgA response was comparable among the infant' groups where heat-labile toxin (LT) fecal IgA was found to be lower in the 6 and 18 months old children, although it was significantly elevated in those 12 and 24 months old children (P= 0.021). This study demonstrated that the maturation of the immune system is mirrored in cellular and humoral immune responses to specific antigens and minimizes the developmental limitations with growing age during infancy.
    Keywords
    Biotechnology
    Description
    This thesis report is submitted in partial fulfillment of the requirement for the degree of Masters of Science in Biotechnology, 2011
     
    Cataloged from PDF version of thesis report.
     
    Includes bibliographical references (page 69-91).
    Department
    Department of Mathematical and Natural Science, BRAC University
    Collections
    • Thesis (Master of Science in Biotechnology)

    Copyright © 2008-2019 Ayesha Abed Library, Brac University 
    Contact Us | Send Feedback
     

     

    Policy Guidelines

    • BracU Policy
    • Publisher Policy

    Browse

    All of BracU Institutional RepositoryCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

    My Account

    LoginRegister

    Statistics

    View Usage Statistics

    Copyright © 2008-2019 Ayesha Abed Library, Brac University 
    Contact Us | Send Feedback