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A novel approach for predicting the evolutionary origin of acquisition of foreign genes in bacteria: application of codon usage analyses

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dc.contributor.advisor Hossain, Dr. Md. Anwar Khan, Md. Moazzem Hossain 2012-03-04T10:15:29Z 2012-03-04T10:15:29Z 2009 2009
dc.identifier.other ID 07276001
dc.description This thesis is submitted in a partial fulfillment of the requirement for the Degree of Masters in Biotechnology . en_US
dc.description Cataloged from PDF version of thesis report.
dc.description Includes bibliographical references (page 87-96).
dc.description.abstract Lysogenic bacteriophages, are considered as a major player for the introduction of foreign genes into bacterial strains. At the time of introduction foreign genes do not fit well into the translation system of the recipient host bacterium as they tend to retain the characteristics of the donor bacteriophages from which it has been transferred. Consequently foreign genes are poorly transcribed at the early phase of their evolution within the host bacterium. This is largely due to the difference in the codon usage pattern between the horizontally transferred genes and the host bacterium. In this study we present detail analyses of various parameters of the codon usages such as codon adaptation index (CAI), mean difference (MD) of the relative adaptiveness, synonymous substitution rate (SSR) of six different phage encoded toxin genes (cholera toxin, shiga toxin, diphtheria toxin, neurotoxin C1, enterotoxin type A and cytotoxin) and proposed conceptual relationship between the evolutionary time of acquisition of the foreign genes and the selected set of parameters of the codon usage. On the basis of the observed data we hypothesize that CAI, MD and SSR of the phage encoded toxin genes are correlated with the evolutionary time of their acquisition and developed a novel approach based on the analyses of these parameters, that can be used to predict the evolutionary time of their acquisition by the corresponding host bacterium. en_US
dc.description.statementofresponsibility Md. Moazzem Hossain Khan
dc.format.extent 96 pages
dc.language.iso en en_US
dc.publisher BRAC University en_US
dc.rights BRAC University thesis are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission
dc.title A novel approach for predicting the evolutionary origin of acquisition of foreign genes in bacteria: application of codon usage analyses en_US
dc.type Thesis en_US
dc.contributor.department Department of Mathematical and Natural Science, BRAC University M. Biotechnology

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