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    • Department of Pharmacy (PHR)
    • Bachelor of Pharmacy
    • Project report (Bachelor of Pharmacy)
    • View Item
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    Investigation of in-vitro antioxidant and cytotoxic activity of Blumea lacera leaf extract

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    15346039_PHR.pdf (1.456Mb)
    Date
    2019-10
    Publisher
    Brac University
    Author
    Khan, Mujtaba Ali
    Metadata
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    URI
    http://hdl.handle.net/10361/13939
    Abstract
    Blumea lacera (family: Asteraceae) is a very potent plant for its various therapeutic properties. This research was intended to detect the antioxidant and cytotoxic potential of chloroform extract of this plant leaf. Antioxidant potential was assessed by a number of in-vitro antioxidant studies and among them DPPH free radical scavenging assay showed 86.43% inhibition of free radicals at 1200μg/mL of the extract with IC50 of 2.39μg/mL. Highest total phenolic content (TPC), total flavonoid content (TFC) and total antioxidant capacity (TAC) was found to be 285.47mg of GAE/g, 287.12mg of QE/g and 272.21mg of AAE/g at 1200μg/mL of extract, respectively. Cytotoxic activity was measured using in-vitro MTT assay against HeLa and MOLT-4 cell lines that showed IC50 of 3.46mg/mL and 3.29mg/mL for the extract. These results showed that the extract had strong antioxidant and low cytotoxic potential.
    Keywords
    Antioxidant; Cytotoxic; Free radical; Phenolic; Flavonoid
     
    LC Subject Headings
    Medicinal plants; Materia medica, Vegetable
     
    Description
    This thesis is submitted in partial fulfilment of the requirements for the degree of Bachelor of Pharmacy, 2019.
     
    Cataloged from PDF version of thesis report.
     
    Includes bibliographical references (pages 69-89).
    Department
    Department of Pharmacy, Brac University
    Collections
    • Project report (Bachelor of Pharmacy)

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