Method development of oil solubility test of Aceclofenac
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The aim of the study was to develop a method that would allow the solubility testing of Aceclofenac in different oils. The main target was to find a suitable method by using commercially available drugs like olive oil. The process involved screening of oil after which extraction was done in a separating funnel in order to differentiate the API using hexane and methanol. The absorbance was taken in UV spectrophotometer and wavelength scan of hexane layer was found out. Series of extraction was done to see up to how many extractions were needed until there was no more API peak in the hexane layer and all the Aceclofenac was dissolved in methanol layer. The results showed that, after 10 times extraction the absorbance of the methanol layer at 277 nm came out 0.78 which falls within the ideal range 0.5-1 and no peak was seen in the hexane layer within the wavelength range.