Evaluation of neuro-pharmacological effects of calabash chalk on Swiss albino Mice
AuthorShova, Luluin Maknun
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In some countries in Asia and Africa, calabash chalk consumption is common which creates safety concerns. The study aims to evaluate the neuro-pharmacological effect of this chalk in mice. Twenty-four female Swiss albino mice weighing 22-28 grams were taken and were randomly divided into 4 groups. The chalk were ingested by oral gavage at the doses of 200, 400 and 600 mg/Kg/day. A control group was treated with distilled water. Four neuro- pharmacological tests were performed. These were: OFT (Open Field Test), EPM (Elevated Plus Maze), HCT (Hole Cross Test), HBT (Hole Board Test). The results showed that there has been a decrease in the locomotor activity and exploratory behavior. It indicates a probable impairment at a neuromuscular level due to a reduction of locomotive activities as a result of calabash chalk consumption. Therefore, necessary caution must be taken while consuming calabash chalk.