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    • Department of Pharmacy (PHR)
    • Bachelor of Pharmacy
    • Project report (Bachelor of Pharmacy)
    • View Item
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    Comparative in vitro quality evaluation of different brands of Ebastine 10 mg tablets commercially available in Bangladesh

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    15146048_PHR.pdf (786.1Kb)
    Date
    2019-08
    Publisher
    Brac University
    Author
    Rahman, Saqib
    Metadata
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    URI
    http://hdl.handle.net/10361/13923
    Abstract
    The main purpose of this study was to evaluate and compare the quality control parameters of twelve different brands of ebastine tablets available in Bangladesh. Different in vitro quality parameters including weight variation, % friability, hardness, disintegration time, dissolution profile and potency were assessed according to the compendial procedures. According to BP specification, all tablets of each brand showed % weight variation within the range. All brands showed their friability within the USP designated limit of less than 0.5%. Within 30 minutes, tablets from all brands disintegrated completely which complies with BP and JP specifications and eight out of twelve brands could not meet the first stage dissolution test. Potency was calculated using UV-spectrometric method and tablets from all brands showed potency not less than 90%. The study illustrates that all brands of ebastine tablets showed acceptable results for the experiments performed except 1st stage dissolution test for few brands.
    Keywords
    Ebastine; BCS class II drug; In vitro quality evaluation; Assay by UV-spectroscopy; Dissolution profile; Conventional oral dosage form
     
    Description
    This thesis is submitted in partial fulfilment of the requirements for the degree of Bachelor of Pharmacy, 2019.
     
    Cataloged from PDF version of thesis report.
     
    Includes bibliographical references (pages 57-63).
    Department
    Department of Pharmacy, Brac University
    Collections
    • Project report (Bachelor of Pharmacy)

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