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dc.contributor.advisorHossain, Mahboob
dc.contributor.authorIslam, Maliha
dc.date.accessioned2020-07-22T06:22:16Z
dc.date.available2020-07-22T06:22:16Z
dc.date.copyright2019
dc.date.issued2019
dc.identifier.otherID 15136003
dc.identifier.urihttp://hdl.handle.net/10361/13896
dc.descriptionThis thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Science in Biotechnology, 2019.en_US
dc.descriptionCataloged from PDF version of thesis.
dc.descriptionIncludes bibliographical references (pages 44-46).
dc.description.abstractHemoglobin E/β Thalassemia is an inherited anemic genetic disorder that is highly prevalent in the Southern Asia part of the world. Bangladesh falls in the Thalassemia belt of the world. The clinical manifestation of this disease is widely heterogeneous. The patients are divided into three groups: severe, moderately severe and non-transfusion dependent. In Bangladesh, data about NTDT (Non-Transfusion Dependent Thalassemia) patients are scarce. However, studying NTDT patients is essential as the factors behind its widely variable clinical diversity are still unknown. Here, the mutation spectrum, hemoglobin profiles, and hematological features are compared between the transfusion-dependent and NTD patients to find a responsible factor behind the disease severity. Among the compared parameters, it had been found that Hb F and Hb E play a role in ameliorating the disease severity because the increase in gamma genes of Hb F decreases the α/β-chain imbalance and the high oxygen dissociation power of HbE. This study can be useful for the correct diagnosis of NTDT patients.en_US
dc.description.statementofresponsibilityMaliha Islam
dc.format.extent46 pages
dc.language.isoenen_US
dc.publisherBrac Universityen_US
dc.rightsBrac University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission.
dc.subjectHaemoglobinen_US
dc.subjectE/β Thalassemiaen_US
dc.subjectNon-transfusion dependent Thalassemiaen_US
dc.subjectDisease severityen_US
dc.subjectHaemoglobin Profilesen_US
dc.subjectHaematological featuresen_US
dc.subject.lcshThalassemia--Diagnosis
dc.titleComparison of mutation spectrum, hemoglobin profiles and hematological features between transfusion dependent and non-dependent patients of Hb E/β Thalassemiaen_US
dc.typeThesisen_US
dc.contributor.departmentDepartment of Mathematics and Natural Sciences, Brac University
dc.description.degreeB. Biotechnology


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