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Toxicological risk of consuming melamine contaminated food products in human body & its detection techniques

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dc.contributor.advisor Akter, Raushanara
dc.contributor.author Tabassum, Fatima
dc.date.accessioned 2018-11-12T04:56:01Z
dc.date.available 2018-11-12T04:56:01Z
dc.date.copyright 2018
dc.date.issued 2018-09
dc.identifier.other ID 13346015
dc.identifier.uri http://hdl.handle.net/10361/10836
dc.description Now-a-days, food adulteration is a burning issue in global food business and as well as for the people who purchase these food items. Adulteration not only disturbs the public health but also abolish the global business. Melamine is one of the poisonous substances that cause harmful effects in the organs of the human body. Melamine that is encompassed of a trimer of cyanamide, which is used as a constituent of plastic in the industry. It contains 66% of nitrogen by mass and due to this high nitrogen content, melamine is added to different nutritional substances raises their protein levels. This literature review revealed that, because of the presence of melamine in powder milk, it causes death of newborns. It was also found that huge number of people became hospitalized in China, Australia, Myanmar, Taiwan, and Bangladesh and in several countries for the issue of renal impairment, central nervous system dysfunction, dysfunction in digestive system and reproductive system due to increase consumption of melamine contaminated food products. According to the reports of WHO, EFSA and FDA, the normal tolerable range of melamine for the human body is 0.2 mg/kg body weight. When the normal range exceeds, it shows the toxicological effects in the body. Therefore, it is essential to determine the level of melamine contamination in food products such as powder milk, powder infant formula, liquid milk etc. There are different techniques available to detect melamine contamination and its level with certain techniques. Among them, HPLC UV, enzyme kit detector, synthetic dye, ion chromatography with UV detector are most importantly used to determine the concentration of melamine present in food products. Toxicokinetic study discovered that melamine might not stay in the body for a long time but it affects more organs of human body than we anticipated. This review work was focused to find out the information on toxicological risk of consuming melamine contaminated food products in human body & its detection techniques. Findings of this review showed that, a number of companies who were involved in the production of milk and baby formula, intentionally adulterated milk product to enhance the protein level. Due to this adulteration, different body organs are exposed to a number of toxicological problems as mentioned above. To conclude, it can be inferred that, this review information will help to create awareness among the general people regarding this issue and it will also help the scientists to get information about melamine toxicity and its detection techniques who want to explore further research in this area. en_US
dc.description Catalogued from PDF version of project report.
dc.description Includes bibliographical references (page 40-51).
dc.description.abstract Now-a-days, food adulteration is a burning issue in global food business and as well as for the people who purchase these food items. Adulteration not only disturbs the public health but also abolish the global business. Melamine is one of the poisonous substances that cause harmful effects in the organs of the human body. Melamine that is encompassed of a trimer of cyanamide, which is used as a constituent of plastic in the industry. It contains 66% of nitrogen by mass and due to this high nitrogen content, melamine is added to different nutritional substances raises their protein levels. This literature review revealed that, because of the presence of melamine in powder milk, it causes death of newborns. It was also found that huge number of people became hospitalized in China, Australia, Myanmar, Taiwan, and Bangladesh and in several countries for the issue of renal impairment, central nervous system dysfunction, dysfunction in digestive system and reproductive system due to increase consumption of melamine contaminated food products. According to the reports of WHO, EFSA and FDA, the normal tolerable range of melamine for the human body is 0.2 mg/kg body weight. When the normal range exceeds, it shows the toxicological effects in the body. Therefore, it is essential to determine the level of melamine contamination in food products such as powder milk, powder infant formula, liquid milk etc. There are different techniques available to detect melamine contamination and its level with certain techniques. Among them, HPLC UV, enzyme kit detector, synthetic dye, ion chromatography with UV detector are most importantly used to determine the concentration of melamine present in food products. Toxicokinetic study discovered that melamine might not stay in the body for a long time but it affects more organs of human body than we anticipated. This review work was focused to find out the information on toxicological risk of consuming melamine contaminated food products in human body & its detection techniques. Findings of this review showed that, a number of companies who were involved in the production of milk and baby formula, intentionally adulterated milk product to enhance the protein level. Due to this adulteration, different body organs are exposed to a number of toxicological problems as mentioned above. To conclude, it can be inferred that, this review information will help to create awareness among the general people regarding this issue and it will also help the scientists to get information about melamine toxicity and its detection techniques who want to explore further research in this area. en_US
dc.description.statementofresponsibility Fatima Tabassum
dc.format.extent 51 pages
dc.language.iso en en_US
dc.publisher BRAC University en_US
dc.rights BRAC University project reports are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission.
dc.subject Melamine en_US
dc.subject Toxic en_US
dc.subject Food products en_US
dc.subject.lcsh Food -- Analysis.
dc.subject.lcsh Melamine -- Testing -- Methodology.
dc.title Toxicological risk of consuming melamine contaminated food products in human body & its detection techniques en_US
dc.type Project report en_US
dc.contributor.department Department of Pharmacy, BRAC University
dc.description.degree B. Pharmacy


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