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A short review on the phenotypic, genotypic and immunological developments for Zika virus

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dc.contributor.advisor Jamiruddin, Dr. Mohd. Raeed Monefa, Marzana 2018-11-08T09:56:55Z 2018-11-08T09:56:55Z 2018 2018-09
dc.identifier.other ID 14146018
dc.description This project report is submitted in partial fulfilment of the requirements for the degree of Bachelor of Pharmacy, 2018. en_US
dc.description Catalogued from PDF version of project report.
dc.description Includes bibliographical references (page 47-67).
dc.description.abstract Zika Virus (ZIKV) has recently received much attention right after the outbreak in America. Initially ZIKV was not considered a dangerous flavivirus as the infections were asymptomatic with only mild complications. But, it became a grave public health concern, when a strong association of ZIKV was proven with various neurological disorders, like for children it was found to cause hereditary deformities and for adults it resulted in Guillain-Barre syndrome. Since then researches and developers are conducting various studies to gain knowledge about the virus for development of safe and effective therapeutic strategy. Considering all ZIKV transmission methods, the transfer of ZIKV from infected pregnant mother to fetus have positioned licensing of an effective vaccination against ZIKV at forefront. Even if there is no approved vaccination yet, various platforms are working with many types of vaccination strategies are progressing at a high rate. Currently, there are many possible candidates in the pipeline of ZIKV vaccines. DNA vaccine candidates has progressed to clinical phase II studies and many vaccine types including mRNA, PIV, LAV, vectored vaccines are exhibiting promising data in both preclinical and clinical studies. Nevertheless, there is still many knowledge gap and challenges which are needed to overcome in the coming years for the successful licensure of ZIKV vaccines. This review article highlights on the structural importance of the virus, defense mechanism of host towards the virus and the up-to-date condition of vaccination development and challenges in the context of ZIKV. en_US
dc.description.statementofresponsibility Marzana Monefa
dc.format.extent 67 pages
dc.language.iso en en_US
dc.publisher BRAC University en_US
dc.rights BRAC University project reports are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission.
dc.subject Zika virus development en_US
dc.subject.lcsh Zika Virus.
dc.title A short review on the phenotypic, genotypic and immunological developments for Zika virus en_US
dc.type Project report. en_US
dc.contributor.department Department of Pharmacy, BRAC University B. Pharmacy

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