Thesis (Master of Science in Biotechnology)
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Mutation patterns in the HBB gene determine the frequency and onset of blood transfusion in patients with beta-thalassemia major and HbE-beta thalassemia
(Brac University, 2019-11)Thalassemia is a blood disorder passed down through families (inherited) in which the body makes an abnormal form or inadequate amount of hemoglobin. Co-inheritance of beta-thalassemia alleles from two parents results ... -
Prospects of Biodegradable Polymer (Polyhydroxyalkanoate) production with wastewater
(Brac University, 2019-10)Plastic production and accumulation have devastating environmental effects, and consequently, the world is in need to focus on environmentally friendly plastic substitutes such as sustainable biofuels, biomaterials, and ... -
A study on the effect of genome size on the multiplication rate of bacteriophages
(Brac University, 2019-09)Bacteriophages encapsidated by a protein coat have the competency of infecting bacteria, are the most abundant living entities on earth whose genome in general falls into three size ranges and 30-50kbp genetic material ... -
Quorum regulated resistance of E. coli against environmental bacteriophages
(Brac University, 2019-09)Predation of bacteria by their corresponding phages have a significant influence on the population structure of different communities of bacteria. E. coli infection has become a safety concern globally and they are causing ... -
Investigation of insulin promoter factor 1 gene C18R and R197H variants association with type 2 diabetes mellitus in Bangladeshi population
(Brac University, 2019-07)Diabetes Mellitus (DM) is a common metabolic disorder, resulting from defects in insulin secretion, insulin action, or both. But the molecular mechanism behind the basic defects of DM is not yet fully understood. Defect ... -
Detection of beta globin gene mutations in thalassemia patients in Bangladesh and correlation with hematological parameters
(Brac University, 2018-12)β-thalassemia and hemoglobin E (Hb E) diseases are highly prevalent autosomal recessive disorders characterized by the reduced or absent expression of the β globin gene. β-thalassemia is now regarded as the most common ... -
Multi-hospital surveillance and antibiotic sensitivity among bacterial isolates of acute respiratory and enteric infection in underfive children in Dhaka, Bangladesh
(BRAC University, 2015-07-27)Acute lower respiratory tract infection (ARI), enteric fever and diarrhea remain the prevalent causes for mortality and morbidity of under-five children in Bangladesh. However, little information is available on true ... -
In silico modelling and structural dynamics of PRR CORE ectodomain and its interaction with PAMP csp22
(BRAC University, 2018-11)Plants being sessile organisms are continuously being subjected to pathogens prevailing in their environment. Understanding the theory behind it would be a great step towards understanding the mechanisms making plants ... -
A study on hematological parameters of tuberculosis patients in Bangladesh
(BRAC University, 2018-11)Among all the infectious diseases, tuberculosis (TB) remains the deadliest. In 2017, the World Health Organization (WHO) ranked Bangladesh 6th among the world’s 22 high-burden TB countries. In this study various hematological ... -
Molecular and phenotypic investigations of enzyme mediated resistance profiles against aminoglycoside antibiotics in gram-negative clinical isolates in Dhaka, Bangladesh
(BRAC University, 2018-09)In recent decades, focus has shifted from notorious Gram-positive pathogens to Gram-negative threats, the majority of which comprise members of the Enterobacteriaceae and Pseudomonadaceae families. These, often commensal ... -
Effect of physical parameters on the decolorization of multiple synthetic textile dyes by bacteria recovered from dye contaminated soil and water
(BRAC University, 2018-07)Textile wastewater is a complex mixture of many contaminating materials. These include a high concentration of salts, acids, heavy metals, organochlorine-based pesticides, pigments, dyes etc. Dye is the first pollutant ... -
Degradation of dyes used in textile Industries by bacteria isolated from local textile effluents
(BRAC University, 2017-06)The effluent discharges from textile processing industries contain a significant amount of unreacted dyes. Release of these dyes into the environment causes toxic effects to the environment. The application of microorganisms ... -
Isolation of cellulolytic bacteria from soil sample and production of cellulase and its purification
(BRAC Univeristy, 2018-03)The cellulase producing bacteria were isolated from cow dung and characterized by morphological and biochemical analysis. Hence, studies pursue to unfold a novel cellulase that can overcome existing challenges in biorefinery, ... -
In vivo propagation of monoclonal antibodies in ascites fluid produced in BALB/c mice: characterization and diagnostic application for the identification of Vibrio cholerae O1
(BRAC University, 2017-07)Monoclonal antibodies are powerful tools in biomedical sciences. High affinity of binding domains of monoclonal antibodies towards a specific antigen enables their use in diagnostic assays and kits to identify particular ... -
Behaviour of gut bacteria upon stress in infants with ileostomy due to Hirschsprung disease
(BRAC University, 2017-06)Hirschsprung disease (HD) is a congenital one where the distal part of intestine lacks nerve ganglions, resulting in failure of defecation through anus. As treatment purpose, a stoma is created temporarily in the abdomen. ... -
Prevalence and molecular characterization of extended spectrum Beta-Lactamase producing multidrug-resistant Pseudomonas aeruginosa and Klebsiella pneumoniae isolates
(2017-06)The discovery of antibiotics has revolutionized health care worldwide. However, the life-saving role of antibiotics is threatened by the emergence of antibiotic- resistant ‘superbugs’. With the emergence of antibiotic ... -
Pattern of brain tumor among admitted patients in a specialized center of Dhaka city: a cross sectional study
(BRAC University, 2017)A brain tumor is an intracranial solid neoplasm which involves varied types of cells. Management strategies and prognosis of tumor depends on the combination of factors like the type and grade of tumor, its location, size ... -
Optimization of transpeptidation reaction of the insulin precursor for efficient yield recovery during downstream processing
(BRAC University, 2017)Nowadays Yeast cell is a popular host for recombinant human insulin production where initially it secrets insulin precursor fusion protein with N-terminal spacer peptide and deletedthreonineB30, followed by a small C-peptide ... -
Vaccine efficacy of 45 kDa outer membrane protein of escherichia coli O157:H7 in Mice Models
(BRAC University, 2017-07)Escherichia coli O157:H7 is an extremely pathogenic organism that produces a potent Shiga toxin which can cause a number of brutal diseases like Hemorrhagic Colitis (bloody diarrhoea), renal failure causing Hemolytic Uremic ... -
Effect of passive immunization with mouse Anti-BCG 64 kDa protein on ehrlich ascites carcinoma cells
(BRAC University, 2017-10)Cancer is one of the leading causes of death now-a-days. There are various treatment options for cancer and each has its own side effects because most of the therapeutic agents of cancer are non-selective and may cause ...
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