Dissolution performance improvement of fenofibrate through secondary solid dispersion using PEG6000 and croscarmellose sodium combination

Abstract

The potential of solid dispersion based formulation using the combination of PEG6000 and croscarmellose sodium as drug carrier to enhance the dissolution performance and oral bioavailability of Fenofibrate, a poorly water soluble drug was investigated. Fenofibrate is a hydrophobic drug in fibrate class of drug which is mainly used in patients at risk of cardiovascular disease in the treatment of hypercholesterolemia and hypertriglyceridemia. Solid dispersions with different drug-to-carrier ratios were prepared by the physical mixture method and solvent method and characterized by dissolution testing within 30minutes. In vitro drug release were performed using US pharmacopeia type II apparatus (paddle-method) in 1000ml distilled water containing 0.75% w/v sodium lauryl sulfate at 75rpm for 30minutes. UV visible spectrophotometric method was selected for dissolution performance investigation at max 290 nm. In physical mixture method F5 (32.5%) and F11 (83%) and in solvent method F6 (39%) and F11 (38.5%) have showed good percentage of drug release.